Cubase all the way, after all, THEY invented the VST.
And they gave all of us, the SDK (software development kit) so WE could create our own.
Update: I added Presonus Studio One Pro Ver.3, and find it easy to run.
It is very powerful, way better than it was 5 years ago.
And it includes alot of plug-ins, which is worth the money, so you get the DAW free.
Steinberg CI2 interface I/O.
Cubase 5 DAW.
Waves Gold Plug-ins.
Fender Strat-o-Caster, and Epiphone Prophet.
Waves GTR Rack 3, this is the sound for the guitars.
Although I do have a small 40 watt Marshall Valvestate,
and POD HD.
Akai MAX 49 midi controller.
A brain and imagination